Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomised, double-blind, placebo-controlled… · PMID 25534187

Hindocha C, Freeman TP, Schafer G, Gardener C, Das RK, Morgan CJ, Curran HV.

Study design: Randomized trial
Population / model: Human
Published: 2014-12-05
Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

From the author abstract

“It provides preliminary evidence that different pharmacological agents acting upon the endocannabinoid system can both improve and impair recognition of emotional faces.”

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Figures from the paper

Figure 1: Percentage accuracy for each intensity, over all emotions and single trial design. Asterisks indicate a significant drug×intensity interaction. (a) Percentage a — **Figure 1** Percentage accuracy for each intensity, over all emotions and single trial design. Asterisks indicate a significant drug×intensity interaction. (a) Percentage accuracy at 20%, (b) significant contrast between THC and Placebo at 40%, (c) significant contrast between CBD and Placebo at 60%, (d) percentage accuracy at 80%, (e) percentage accuracy at 100%, and (f) design of a single trial in the emotional processing task. Error bars represent standard error of the mean (±SEM).Hindocha C, Freeman TP, Schafer G, Gardener C, Das RK, Morgan CJ, Curran HV. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2014). Original figure · CC BY · Resized for display.

Figure 2: (a) Recognition of all emotions over the different intensities. Asterisks׳ illustrate a significant drug by intensity interaction where at 40%, we found a signi — **Figure 2** (a) Recognition of all emotions over the different intensities. Asterisks׳ illustrate a significant drug by intensity interaction where at 40%, we found a significant contrast between placebo and THC; at 60%, a significant contrast between placebo and CBD and at 100%, no significant contrast after correction for multiple comparisons.Hindocha C, Freeman TP, Schafer G, Gardener C, Das RK, Morgan CJ, Curran HV. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2014). Original figure · CC BY · Resized for display.

Citation and indexing details

PMID 25534187 · PMC4398332

Publication types: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Topic tags: Psychiatry & cognition

Metadata checked 2026-11-04. Study design and model tags follow indexing and explicit abstract terms. Citation counts are not evidence of benefit. An available full text does not by itself permit image reuse.