CannaCompare

Randomized trial · 2018

Acute Effects of Smoked and Vaporized Cannabis in Healthy Adults Who Infrequently Use Cannabis: A Crossover Trial.

THCCannabis formulations

Spindle TR, Cone EJ, Schlienz NJ, Mitchell JM, Bigelow GE, Flegel R, Hayes E, Vandrey R.

Study design
Randomized trial
Population / model
Human
Published
2018-11-02
Journal
JAMA network open
Sample mentioned
17 adults — Number stated in the abstract; not independently verified.

From the author abstract

“The sample included 17 healthy adults (mean [SD] age, 27.3 [5.7] years; 9 men and 8 women) with no cannabis use in …”

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Figures from the paper

Figure 1. CONSORT Flow DiagramTHC indicates Δ9-tetrahydrocannabinol.Spindle TR, Cone EJ, Schlienz NJ, Mitchell JM, Bigelow GE, Flegel R, Hayes E, Vandrey R. JAMA network open (2018). Original figure · CC BY · Resized for display.
Figure 2. Mean Ratings for Visual Analog Scale (VAS) Item Drug Effect From the Drug Effect Questionnaire Displayed Over Time and Across Δ9-Tetrahydrocannabinol Dose for Smoked and Vaporized ConditionsScores ranged from 0 (not at all) to 100 (extremely). Error bars indicate SEM. Horizontal axes are not accurate time scales and represent the time points at which subjective drug effects were assessed. BL indicates baseline time point; and Δ, difference or change.Spindle TR, Cone EJ, Schlienz NJ, Mitchell JM, Bigelow GE, Flegel R, Hayes E, Vandrey R. JAMA network open (2018). Original figure · CC BY · Resized for display.
Citation and indexing details

PMID 30646391 · PMC6324384

Publication types: Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.

Topic tags: Psychiatry & cognition; Safety & interactions

Metadata checked 2026-11-04. Study design and model tags follow indexing and explicit abstract terms. Citation counts are not evidence of benefit. An available full text does not by itself permit image reuse.