CannaCompare

Randomized trial · 2019

Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy.

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Pretzsch CM, Voinescu B, Lythgoe D, Horder J, Mendez MA, Wichers R, Ajram L, Ivin G, Heasman M, Edden RAE, Williams S, Murphy DGM, Daly E, McAlonan GM.

Study design
Randomized trial
Population / model
Human
Published
2019-11-20
Journal
Translational psychiatry

From the author abstract

“Future studies should examine the effect of CBDV on behaviour and if the response to an acute dose of CBDV could predict …”

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Figures from the paper

Fig. 1 a Glx (glutamate + glutamine) in the basal ganglia and dorsomedial prefrontal cortex for both groups in both drug conditions. Glx concentration (y-axis) represents the ratio of the Glx metabolite resonance area to the unsuppressed water resonance area. b Drug-induced shift in Glx in the basal ganglia. ΔGlx (y-axis) represents the cannabidivarin (CBDV)-induced shift in Glx concentration compared to placebo (PLC), i.e. CBDV-PLC. Group means are indicated by black horizonal bars. Error bars represent standard deviations. c gamma-aminobutyric acid + macromolecules (GABA+) in the basal ganglia and dorsomedial prefrontal cortex for both groups in both drug conditions. GABA+ concentration (y-axis) represents the ratio of the GABA+ metabolite resonance area to the unsuppressed water resonance area. d Correlation between Glx at baseline and CBDV-induced shift in Glx (ΔGlx) in the basal ganglia. ASD Autism spectrum disorder, BG Basal ganglia, CBDV Cannabidivarin, DMPFC Dorsomedial prefrontal cortex, Glx glutamate + glutamine, ns Not significant, PLC Placebo, TD Typically developing controls, * indicates a significance level at p ≤ 0.05.Pretzsch CM, Voinescu B, Lythgoe D, Horder J, Mendez MA, Wichers R, Ajram L, Ivin G, Heasman M, Edden RAE, Williams S, Murphy DGM, Daly E, McAlonan GM. Translational psychiatry (2019). Original figure · CC BY · Resized for display.
Citation and indexing details

PMID 31748505 · PMC6868232

Publication types: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Topic tags: Neurology

Metadata checked 2026-11-04. Study design and model tags follow indexing and explicit abstract terms. Citation counts are not evidence of benefit. An available full text does not by itself permit image reuse.