Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis. · PMID 32197092

Hindley G, Beck K, Borgan F, Ginestet CE, McCutcheon R, Kleinloog D, Ganesh S, Radhakrishnan R, D'Souza DC, Howes OD.

Study design: Meta-analysis
Population / model: Human
Published: 2020-03-17
Journal: The lancet. Psychiatry

From the author abstract

“15 eligible studies involving the acute administration of THC and four studies on CBD plus THC administration were identified. Compared with placebo, …”

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Figures from the paper

Figure 1: Study selectionBPRS=Brief Psychiatric Rating Scale. CBD=cannabidiol. PANSS=Positive and Negative Syndrome Scale. THC=Δ9-tetrahydrocannabinol. — **Figure 1** Study selectionBPRS=Brief Psychiatric Rating Scale. CBD=cannabidiol. PANSS=Positive and Negative Syndrome Scale. THC=Δ9-tetrahydrocannabinol.Hindley G, Beck K, Borgan F, Ginestet CE, McCutcheon R, Kleinloog D, Ganesh S, Radhakrishnan R, D'Souza DC, Howes OD. The lancet. Psychiatry (2020). Original figure · CC BY · Resized for display.

Figure 2: Forest plot of total psychiatric symptom severity following THC relative to placeboThe size of the squares reflects the weight attributed to each study. Exact s — **Figure 2** Forest plot of total psychiatric symptom severity following THC relative to placeboThe size of the squares reflects the weight attributed to each study. Exact study weights are presented in the appendix (p 13). The diamond denotes the summary effect size for the random-effects model for all studies, and the width of the diamond depicts the overall 95% CI. THC=Δ9-tetrahydrocannabinol. *Low cannabis use sample. †High cannabis use sample.Hindley G, Beck K, Borgan F, Ginestet CE, McCutcheon R, Kleinloog D, Ganesh S, Radhakrishnan R, D'Souza DC, Howes OD. The lancet. Psychiatry (2020). Original figure · CC BY · Resized for display.

Citation and indexing details

PMID 32197092 · PMC7738353

Publication types: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review

Topic tags: Psychiatry & cognition

Metadata checked 2026-11-04. Study design and model tags follow indexing and explicit abstract terms. Citation counts are not evidence of benefit. An available full text does not by itself permit image reuse.