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Randomized trial · 2022

Driving Performance and Cannabis Users' Perception of Safety: A Randomized Clinical Trial.

THCCannabis formulations

Marcotte TD, Umlauf A, Grelotti DJ, Sones EG, Sobolesky PM, Smith BE, Hoffman MA, Hubbard JA, Severson J, Huestis MA, Grant I, Fitzgerald RL.

Study design
Randomized trial
Population / model
Human
Published
2022-03-01
Journal
JAMA psychiatry

From the author abstract

“Of 191 cannabis users, 118 (61.8%) were male, the mean (SD) age was 29.9 (8.3) years, and the mean (SD) days of …”

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Figures from the paper

Figure 1. CONSORT Diagram Showing Participant Inclusion/Exclusion From Initial Screening to Final SampleUTOX+ indicates urine toxicology; THC, tetrahydrocannabinol.Marcotte TD, Umlauf A, Grelotti DJ, Sones EG, Sobolesky PM, Smith BE, Hoffman MA, Hubbard JA, Severson J, Huestis MA, Grant I, Fitzgerald RL. JAMA psychiatry (2022). Original figure · CC BY · Resized for display.
Figure 2. Change in Simulator Performance Over Time, Distribution of Simulator Changes at 30 Minutes, and Relationship Between Self-reported Impairment and Objective Driving Simulator PerformanceA, Change in Composite Drive Score (CDS) from baseline: all 3 treatment groups. Values are means (95% CIs). B, Distribution of changes in the CDS from presmoking to 30 minutes postsmoking; shapes represent individual values, the boxes show the 25th, 50th (median), and 75th percentiles. C, Relationship between participant median self-report of driving impairment (light blue line), willingness to refrain from driving (columns showing percent of participants who would not drive: 30 minutes, 52.5%; 1 hour 30 minutes, 31.4%; 3 hours 30 mininutes, 10.1%; and 4 hours 30 minutes, 6.8%), and CDS (dark blue line) (tetrahydrocannabinol [THC] participants only).Marcotte TD, Umlauf A, Grelotti DJ, Sones EG, Sobolesky PM, Smith BE, Hoffman MA, Hubbard JA, Severson J, Huestis MA, Grant I, Fitzgerald RL. JAMA psychiatry (2022). Original figure · CC BY · Resized for display.
Citation and indexing details

PMID 35080588 · PMC8792796

Publication types: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Topic tags: Safety & interactions

Metadata checked 2026-11-04. Study design and model tags follow indexing and explicit abstract terms. Citation counts are not evidence of benefit. An available full text does not by itself permit image reuse.