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Randomized trial · 2023

Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial.

CBDTHCCannabis formulations

Zamarripa CA, Spindle TR, Surujunarain R, Weerts EM, Bansal S, Unadkat JD, Paine MF, Vandrey R.

Study design
Randomized trial
Population / model
Human
Published
2023-02-01
Journal
JAMA network open

From the author abstract

“The participant cohort of 18 adults included 11 males (61.1%) and 7 females (38.9%) with a mean (SD) age of 30 (7) …”

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Figures from the paper

Figure 1. Flow Diagram of Trial Participants CBD indicates cannabidiol; THC, tetrahydrocannabinol.Zamarripa CA, Spindle TR, Surujunarain R, Weerts EM, Bansal S, Unadkat JD, Paine MF, Vandrey R. JAMA network open (2023). Original figure · CC BY · Resized for display.
Figure 2. Mean Plasma Concentration vs Time Profiles for (A) Δ9-THC, (B) 11-OH-Δ9-THC, and (C) Δ9-THC-COOHMean plasma concentration vs time profiles for (A) Δ9-THC, (B) 11-OH-Δ9-THC, and (C) Δ9-THC-COOH. Horizontal axes are not accurate time scales and represent the time points at which subjective drug effects were assessed following cannabis administration. Panels D, E, and F depict area under-the-curve ratios of 11-OH-Δ9-THC:Δ9-THC, Δ9-THC-COOH:Δ9-THC, and Δ9-THC-COOH:11-OH-Δ9-THC, respectively. Error bars indicate standard error of the means. The sample size was 18 for all outcomes. CBD indicates cannabidiol; CYP, cytochrome P450; Δ9-THC, Δ9-tetrahydrocannabinol; Δ9-THC-COOH, 11-nor-Δ9-tetrahydrocannabinol-carboxylic acid; 11-OH-Δ9-THC, 11-hydroxy-Δ9-tetrahydrocannabinol.Zamarripa CA, Spindle TR, Surujunarain R, Weerts EM, Bansal S, Unadkat JD, Paine MF, Vandrey R. JAMA network open (2023). Original figure · CC BY · Resized for display.
Citation and indexing details

PMID 36780161 · PMC9926328

Publication types: Randomized Controlled Trial; Journal Article; Research Support, N.I.H., Extramural

Topic tags: Formulation & pharmacokinetics

Metadata checked 2026-11-04. Study design and model tags follow indexing and explicit abstract terms. Citation counts are not evidence of benefit. An available full text does not by itself permit image reuse.