Cannabinoid exposure across substance use disorders: Short-term symptom benefits without sustained therapeutic gains in a tier-weighted systematic review. · PMID 42466639

Zammit Dimech D, Zammit Dimech AA, Grech L, Serracino Inglott A.

Study design: Systematic review
Population / model: Human
Published: 2026-07-17
Journal: European psychiatry : the journal of the Association of European Psychiatrists

From the author abstract

“Ninety-seven studies (41,954 participants) contributed 195 endpoint instances: 89 Beneficial (45.6%), 80 No Significant Effect (41.0%), 12 Mixed/Partial (6.2%), and 14 Harmful/Inferior …”

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Figures from the paper

Figure 1.: PRISMA 2020 flow diagram for the systematic review. PubMed: 4,539 records; Embase: 6,595 records; total: 11,134; duplicates removed: 1,758; records screened: 9, — **Figure 1.** PRISMA 2020 flow diagram for the systematic review. PubMed: 4,539 records; Embase: 6,595 records; total: 11,134; duplicates removed: 1,758; records screened: 9,376; records excluded: 9,252; full-text articles assessed: 124; articles excluded with reasons: 27; studies included: 97. Figure 1. long description.Zammit Dimech D, Zammit Dimech AA, Grech L, Serracino Inglott A. European psychiatry : the journal of the Association of European Psychiatrists (2026). Original figure · CC BY · Resized for display.

Figure 2.: SUD endpoint instance counts and tier-weighted totals by direction-of-effect category and substance use disorder. Panel A shows raw endpoint instance counts; Pa — **Figure 2.** SUD endpoint instance counts and tier-weighted totals by direction-of-effect category and substance use disorder. Panel A shows raw endpoint instance counts; Panel B shows tier-weighted score totals. SUD indicates substance use disorder; OUD, opioid use disorder; AUD, alcohol use disorder; CoUD, cocaine use disorder; TUD, tobacco use disorder; MUD, methamphetamine use disorder. Figure 2. long description.Zammit Dimech D, Zammit Dimech AA, Grech L, Serracino Inglott A. European psychiatry : the journal of the Association of European Psychiatrists (2026). Original figure · CC BY · Resized for display.

Citation and indexing details

PMID 42466639 · PMC13420148

Publication types: Journal Article; Systematic Review

Topic tags: Substance use; Metabolism & appetite

Metadata checked 2026-11-04. Study design and model tags follow indexing and explicit abstract terms. Citation counts are not evidence of benefit. An available full text does not by itself permit image reuse.