Treating insomnia symptoms with medicinal cannabis: a randomized, crossover trial of the efficacy of a cannabinoid medicine compared with placebo. · PMID 34115851

Walsh JH, Maddison KJ, Rankin T, Murray K, McArdle N, Ree MJ, Hillman DR, Eastwood PR.

Study design: Randomized trial
Population / model: Human
Published: 2021-11-01
Journal: Sleep

From the author abstract

“Twenty-three of 24 randomized participants (n = 20 female, mean age 53 ± 9 years) completed the protocol. No serious adverse events …”

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Outcome summaries · provisional

Selected source sets; evidence confidence remains ungraded.

CBN and wake after sleep onset in insomnia →

Figures from the paper

Figure 1.: CONSORT flow diagram of participants at each phase of the trial. — **Figure 1.** CONSORT flow diagram of participants at each phase of the trial.Walsh JH, Maddison KJ, Rankin T, Murray K, McArdle N, Ree MJ, Hillman DR, Eastwood PR. Sleep (2021). Original figure · CC BY · Resized for display.

Figure 2.: Individual (A) and group mean (±SD) (B) ISI scores for all participants (n = 23) at baseline and during treatment with ZTL-101 and placebo. — **Figure 2.** Individual (A) and group mean (±SD) (B) ISI scores for all participants (n = 23) at baseline and during treatment with ZTL-101 and placebo.Walsh JH, Maddison KJ, Rankin T, Murray K, McArdle N, Ree MJ, Hillman DR, Eastwood PR. Sleep (2021). Original figure · CC BY · Resized for display.

Citation and indexing details

PMID 34115851 · PMC8598183

Publication types: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Topic tags: Sleep

Metadata checked 2026-11-04. Study design and model tags follow indexing and explicit abstract terms. Citation counts are not evidence of benefit. An available full text does not by itself permit image reuse.