Adults with physician-diagnosed insomnia disorder in the selected acute crossover trial
Studied preparation
Defined CBN oral preparations and matched placebo
Route
oral
Primary outcome
Polysomnographic wake-after-sleep-onset minutes; secondary sleep measures kept separate
Study scope
Single-night arms in one three-arm crossover cohort; repeated observations do not multiply participant or trial counts
Reported finding · selected human evidence
Neither CBN contrast clearly improved the primary objective wake-after-sleep-onset outcome. Findings on other sleep measures do not establish primary-outcome success.
One small, single-night crossover cohort; sustained benefit and long-term safety remain unresolved.
1 distinct randomized cohort in this source set. Mixed-cannabinoid medicinal-cannabis trial is a different preparation and not evidence for CBN alone.
Reported effects and harms
Estimates retain their original comparator, units and 95% confidence interval (CI). Different measures are not pooled. Study regimens identify the research; they are not treatment instructions.
20 adults received all three conditions and were analyzed. Repeated observations are not 60 different participants.
Both primary confidence intervals include zero.
Contrast
Measure
Estimate
95% CI
30 mg CBN versus placebo
Wake-after-sleep-onset difference
−4.0 minutes
−15.9 to +7.9 minutes
300 mg CBN versus placebo
Wake-after-sleep-onset difference
−6.3 minutes
−18.2 to +5.5 minutes
Harms reported
247 mild-to-moderate events were recorded across conditions. This is an event total, not a participant count; no formal adverse-event hypothesis test was performed.
Interpretation limits
Small selected sample, one night per condition and many outcomes; no formal sample-size calculation.
Source depth
Primary full text: Methods 2.6–2.9, Results and adverse events.
No animal context selected in this pilot source set.
Laboratory context
No laboratory context selected in this pilot source set.
Source checks and notices
The selected PubMed records were checked 2026-11-08 UTC. No other notice signals were returned for these records at that check; missing metadata signals do not prove that no notice exists. This monitor checks citation relations, not every full-text change, and never rewrites a finding automatically.
Research context, not a recommendation for a medicine, dose or retail product. Findings for the studied preparation do not establish equivalence to products in the catalog.