Randomized trial · 2026

Cannabinol for Acute Treatment of Insomnia Disorder in a Randomized Placebo-Controlled Crossover Trial.

Lavender IG, Marshall NS, McCartney D, Cho G, Irwin C, Suraev A, Gordon R, Arnold JC, D'Rozario AL, Gordon CJ, Saini B, Sivam S, Zheng Y, Grunstein RR, Yee BJ, McGregor IS, Hoyos CM.

Study design
Randomized trial
Population / model
Human
Published
2026-02-16
Journal
Journal of sleep research

Reviewed study note

What this study reported

The primary wake-after-sleep-onset outcome was not significantly changed; some secondary measures differed and adverse events were recorded.

Population
20 adults with physician-diagnosed insomnia disorder.
Studied preparation
Defined oral CBN preparations compared with matched placebo.
Interpretation limit
Single-night arms and a small sample do not establish sustained benefit, broad safety or equivalence to retail sleep products.
Original reviewed note →

From the author abstract

“Larger, longer trials are warranted.”

A short attributed excerpt. Read the full abstract and original paper for methods, results and limitations.

Outcome summaries · provisional

Selected source sets; evidence confidence remains ungraded.

CBN and wake after sleep onset in insomnia →

Citation and indexing details

PMID 41698831 · PMC13357646

Publication types: Journal Article; Randomized Controlled Trial

Topic tags: Sleep

Metadata checked 2026-11-04. Study design and model tags follow indexing and explicit abstract terms. Citation counts are not evidence of benefit. An available full text does not by itself permit image reuse.