Human2026-02-16
Sleep · CBN
Cannabinol for Acute Treatment of Insomnia Disorder in a Randomized Placebo-Controlled Crossover Trial
Journal of sleep research · PMID 41698831
Randomized placebo-controlled single-night crossover trial
- Studied preparation
- Defined oral CBN preparations compared with matched placebo.
- Population / model
- 20 adults with physician-diagnosed insomnia disorder.
- What was observed
- The primary wake-after-sleep-onset outcome was not significantly changed; some secondary measures differed and adverse events were recorded.
Interpretation limit
Single-night arms and a small sample do not establish sustained benefit, broad safety or equivalence to retail sleep products.
Online publication · Source checked 2026-10-25
Sources, registration and terms
Citation and publication date recorded; peer-review/preprint status not separately classified.
PMC full-text link is recorded; current access and reuse rights are not verified here.
Registry state is a dated sponsor report; it does not confirm current recruitment or establish benefit.
- Results paper for this recorded registration
NCT05344170 registry context · Original NCT05344170
No results tables posted in registry
Status: Completed — sponsor-reported. Registry updated 2024-02-06; source checked 2026-10-25.
CBN / cannabinol · Human study · Registered trial · Primary versus secondary outcome