Home Learn Cannabinoid research & its limitations A clearer reading
Cannabinoid research & its limitations Browse the existing curated papers by study context, source links and publication date.
Content reviewed 2026-10-25 · Local preview
Library Research Registered studies Lessons Glossary Guides Curated examples of primary research, not a systematic or complete review. Selection does not depend on affiliate status.
9 of 9 papers
All papers are shown. These filters need JavaScript; use your browser’s Find command or the topic links below.
Human 2026-02-16
Sleep · CBN
Journal of sleep research · PMID 41698831
Randomized placebo-controlled single-night crossover trial
Studied preparation Defined oral CBN preparations compared with matched placebo. Population / model 20 adults with physician-diagnosed insomnia disorder. What was observed The primary wake-after-sleep-onset outcome was not significantly changed; some secondary measures differed and adverse events were recorded. Interpretation limit Single-night arms and a small sample do not establish sustained benefit, broad safety or equivalence to retail sleep products.
Online publication · Source checked 2026-10-25
Sources, registration and terms Citation and publication date recorded; peer-review/preprint status not separately classified.
PMC full-text link is recorded; current access and reuse rights are not verified here.
Registry state is a dated sponsor report; it does not confirm current recruitment or establish benefit.
CBN / cannabinol · Human study · Registered trial · Primary versus secondary outcome
Human 2024-07-13
Anxiety and stress · CBG
Scientific reports · PMID 39003387
Double-blind placebo-controlled crossover field trial
Studied preparation Single-batch CBG tincture also containing CBGA and terpenes. Population / model 34 healthy adults with prior cannabis-product experience; sessions were conducted remotely. What was observed Some self-reported anxiety and stress measures favored the tested formulation. Interpretation limit Small, acute field trial in a selected population; not a treatment trial for an anxiety disorder and not evidence for every CBG product.
Online publication · Source checked 2026-10-25
Sources, registration and terms Citation and publication date recorded; peer-review/preprint status not separately classified.
PMC full-text link is recorded; current access and reuse rights are not verified here.
Registry state is a dated sponsor report; it does not confirm current recruitment or establish benefit.
CBG / cannabigerol · Human study · Registered trial · Primary versus secondary outcome
Human 2022-05-30
Cognition and driving · CBD
Journal of psychopharmacology (Oxford, England) · PMID 35637624
Randomized double-blind crossover trial
Studied preparation Oral CBD preparations compared with placebo in separate acute sessions. Population / model 17 healthy adults studied in controlled simulated-driving sessions. What was observed Several simulator comparisons met the study’s non-inferiority criterion; others were inconclusive. Interpretation limit Small acute simulator study; this is not permission to drive after using CBD, THC-containing products or combinations.
Online publication · Source checked 2026-10-25
Sources, registration and terms Citation and publication date recorded; peer-review/preprint status not separately classified.
PMC full-text link is recorded; current access and reuse rights are not verified here.
Registry state is a dated sponsor report; it does not confirm current recruitment or establish benefit.
Recorded registration ID; registry status/results not checked in this library Original ACTRN12619001552178 CBD / cannabidiol · Human study · Registered trial · Primary versus secondary outcome
Animal In vitro 2021-01-19
Antimicrobial models · CBD
Communications biology · PMID 33469147
Bacterial assays and animal experiments
Studied preparation CBD and related compounds studied in defined preclinical systems. Population / model Bacterial cultures and biofilms, with complementary in-vivo experiments. What was observed The work examined bacterial growth, biofilms, mechanism and topical in-vivo activity. Interpretation limit Preclinical findings are not evidence that a retail CBD product treats infection in humans; no human infection trial was reported.
Online publication · Source checked 2026-10-25
Sources, registration and terms Citation and publication date recorded; peer-review/preprint status not separately classified.
PMC full-text link is recorded; current access and reuse rights are not verified here.
No registration recorded for this paper; this is not a claim that none exists.
CBD / cannabidiol · Animal study · In vitro
Human 2020-07-28
Substance-use research · CBD
The lancet. Psychiatry · PMID 32735782
Phase 2a randomized adaptive trial
Studied preparation Controlled oral CBD preparations compared with matched placebo. Population / model 82 participants with cannabis use disorder attempting cessation; all received motivational interviewing. What was observed Some treatment arms met prespecified adaptive endpoint criteria for cannabis-use reduction. Interpretation limit Early dose-finding study with a concurrent psychological intervention; it does not support self-treatment with a shop product.
Online publication · Source checked 2026-10-25
Sources, registration and terms Citation and publication date recorded; peer-review/preprint status not separately classified.
PMC full-text link is recorded; current access and reuse rights are not verified here.
Registry state is a dated sponsor report; it does not confirm current recruitment or establish benefit.
CBD / cannabidiol · Human study · Registered trial · Primary versus secondary outcome
Human 2017-05-25
Epilepsy · CBD
The New England journal of medicine · PMID 28538134
Randomized placebo-controlled add-on trial
Studied preparation Purified CBD oral solution added to existing antiseizure treatment. Population / model 120 children and young adults with Dravet syndrome and drug-resistant seizures. What was observed The tested formulation reduced convulsive-seizure frequency relative to placebo; adverse events were more frequent. Interpretation limit A specific severe epilepsy population and prescription-style formulation; findings do not establish benefits or safety of retail CBD oils.
Journal publication · Source checked 2026-10-25
Sources, registration and terms Citation and publication date recorded; peer-review/preprint status not separately classified.
No full-text link recorded here; a DOI does not promise free full text.
Registry state is a dated sponsor report; it does not confirm current recruitment or establish benefit.
CBD / cannabidiol · Human study · Registered trial · Primary versus secondary outcome
Animal 2015-01
Neurological models · CBG
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · PMID 25252936
Two experimental mouse models
Studied preparation CBG administered in controlled experimental regimens. Population / model R6/2 mice and mice exposed to a chemical model of Huntington-like injury. What was observed Behavioral and molecular effects differed between the two models. Interpretation limit Preclinical models cannot establish clinical benefit in people with Huntington’s disease or validate a retail formulation.
Journal issue · Source checked 2026-10-25
Sources, registration and terms Citation and publication date recorded; peer-review/preprint status not separately classified.
PMC full-text link is recorded; current access and reuse rights are not verified here.
No registration recorded for this paper; this is not a claim that none exists.
CBG / cannabigerol · Animal study
In vitro 2008-03-19
Receptor mechanisms · CBD, CBG, CBC, CBDA, THC, THCA
The Journal of pharmacology and experimental therapeutics · PMID 18354058
Cell and isolated-neuron assays
Studied preparation Individual phytocannabinoids tested in defined channel assays. Population / model Engineered HEK-293 cells and isolated rat sensory neurons. What was observed The experiments measured channel-related calcium responses under laboratory conditions. Interpretation limit Mechanistic cell activity does not establish human symptom relief; concentrations and test systems do not map directly onto a bottle.
Online publication · Source checked 2026-10-25
Sources, registration and terms Citation and publication date recorded; peer-review/preprint status not separately classified.
No full-text link recorded here; a DOI does not promise free full text.
No registration recorded for this paper; this is not a claim that none exists.
CBD / cannabidiol · CBG / cannabigerol · CBC / cannabichromene · Acidic cannabinoids: CBDA / THCA · THC / delta-9 THC · In vitro
Animal In vitro 2000-08
Inflammation models · CBD
Proceedings of the National Academy of Sciences of the United States of America · PMID 10920191
Mouse models with complementary cell experiments
Studied preparation CBD administered under controlled laboratory conditions. Population / model Mice with experimentally induced arthritis, plus immune-cell experiments. What was observed Arthritis-related and immune readouts changed in the experimental systems. Interpretation limit Animal disease models and cell experiments are not human treatment outcomes; route, formulation and exposure differ from retail use.
Journal issue · Source checked 2026-10-25
Sources, registration and terms Citation and publication date recorded; peer-review/preprint status not separately classified.
PMC full-text link is recorded; current access and reuse rights are not verified here.
No registration recorded for this paper; this is not a claim that none exists.
CBD / cannabidiol · Animal study · In vitro
No papers match these filters. Clear filters or try a broader search.
Read the study conditions. Study systems, preparations, populations and endpoints answer different questions. A paper does not verify a vendor’s batch or show that a listed retail product reproduces its results. A full-text link does not establish reuse permission. Publication and source-check dates are separate.
Registered studies · Primary versus secondary outcomes · Package comparison guides
Suggest a source correction Copy a note and share it with the person who sent this preview. This page does not send or store your note.
Keep the study preparation in view Read the population, formulation, comparison, measured outcome and limitations beside the citation. A study record about one preparation is not a verification of a retail package. Use the study-reading lesson to distinguish what was measured from a broader claim.