Devinsky et al. (2017) · primary
Defined oral purified CBD, adjunctive Dravet convulsive-seizure outcome; author abstract only.
Outcome summaries · provisional pilot
Selection and source checks
Reproduce the bounded searches and see which sources were selected, separated or left unresolved.
What this pilot covers
Selected-source pilot, not an exhaustive systematic review. Questions and named primary sources were scoped before these bounded discovery searches.
One PubMed page per question, maximum 50 results. Unreturned and unselected Dravet hits were not screened. Search hits alone are not included evidence. This is not a current complete estimate of benefit for each condition.
Publication cutoff 2026-11-08. Scientific editorial review remains pending; selected source checks do not constitute a formal evidence appraisal.
CBD and convulsive seizures in Dravet syndrome
50 of 91 index results retained. The result sample is truncated.
(cannabidiol[Title/Abstract]) AND (Dravet[Title/Abstract]) AND (randomized[Title/Abstract] OR placebo[Title/Abstract]) AND ("1900/01/01"[Date - Publication] : "2026/11/08"[Date - Publication])Run the recorded PubMed query ↗
Selection decisions
Miller et al. (2020) · primary
Distinct randomized Dravet cohort; two active arms share one placebo group. Fulltext extracted; collaborator-name correction retained.
Dravet safety and pharmacokinetics · safety context
Dravet dose-ranging safety/pharmacokinetic Part A; not counted as another trial of the selected efficacy outcome.
Dravet open-label extension · overlapping extension
Open-label continuation includes prior trial participants; no independent randomized control cohort.
Mouse Dravet model · animal context
Mouse Dravet model; cannot increase the human efficacy trial count.
CBN and wake after sleep onset in insomnia
3 of 3 index results retained. The bounded query returned all its index hits; this does not establish an exhaustive evidence review.
(cannabinol[Title/Abstract]) AND (insomnia[Title/Abstract]) AND (crossover[Title/Abstract] OR "single-night"[Title/Abstract]) AND ("1900/01/01"[Date - Publication] : "2026/11/08"[Date - Publication])Run the recorded PubMed query ↗
Selection decisions
Lavender et al. (2026) · primary
One acute crossover insomnia cohort, CBN isolate versus placebo, objective primary WASO outcome.
Mixed-cannabinoid insomnia trial · different preparation
Mixed cannabinoids, sublingual route and repeated nights; not CBN-isolate acute evidence.
Oral CBD add-on and knee osteoarthritis pain
7 of 7 index results retained. The bounded query returned all its index hits; this does not establish an exhaustive evidence review.
(cannabidiol[Title/Abstract]) AND (knee[Title/Abstract]) AND (osteoarthritis[Title/Abstract]) AND (randomized[Title/Abstract] OR placebo[Title/Abstract]) AND ("1900/01/01"[Date - Publication] : "2026/11/08"[Date - Publication])Run the recorded PubMed query ↗
Selection decisions
Pramhas et al. (2023) · primary
Defined oral CBD add-on to continued paracetamol, knee-osteoarthritis pain at eight weeks.
Rat osteoarthritis model · animal context
Rat model and local administration differ from oral human knee trial.
Additional discovery and unresolved records
These hits were not included as primary evidence. Title-level classification is not full scientific screening.
PMID 37612115 · protocol identified
Indexed title identifies CUPID CBN protocol; not another efficacy result. Exact registry/cohort linkage still requires protocol verification.
Original index record ↗PMID 39980821 · not selected
Title identifies cannabinoid supplement and subthreshold insomnia; no assumption of the selected CBN-isolate/diagnosed-insomnia population. Full scientific screening pending.
Original index record ↗PMID 42893197 · secondary review
Indexed narrative review; not an additional primary randomized cohort.
Original index record ↗PMID 42032682 · protocol different setting
Indexed title describes postsurgical knee-arthroplasty protocol; not the selected chronic osteoarthritis outcome report.
Original index record ↗PMID 41487518 · not selected
Title identifies CBD-rich cannabis oil CANOA trial. Different preparation potentially relevant to a broader question; not screened or substituted for purified CBD evidence.
Original index record ↗PMID 39256070 · different route preparation
Title identifies topical hemp seed oil; does not answer selected oral CBD add-on question.
Original index record ↗PMID 40956916 · unresolved
Returned in search; bounded EFetch did not supply usable title/record metadata. No inference or inclusion.
Original index record ↗PMID 40238954 · unresolved
Returned in search; bounded EFetch did not supply usable title/record metadata. No inference or inclusion.
Original index record ↗